Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation
Phytomedicine
– Koichiro Mori & Al.
Experiment: in vitro (rabbit blood)
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Platelet aggregation is a process in which blood platelets clump together and form a clot. This clot can block blood vessels and cause serious problems, such as a heart attack or stroke.

Hericenones B were isolated from the mushroom Hericium erinaceus. These compounds were tested on rabbit blood and showed that they inhibited collagen-induced platelet aggregation. Collagen is a protein found in the walls of blood vessels.

Hericenones B did not inhibit platelet aggregation induced by other substances, such as ADP, adrenaline, or arachidonate. This suggests that hericenones B block a specific mechanism of platelet aggregation, namely the one activated by collagen.

Hericenones B could pave the way for new treatments to prevent or treat certain types of cardiovascular diseases. However, further studies are needed to confirm these results.