Effects of Hericium erinaceus polypeptide on lowering blood lipids of mice with hyperlipidemia induced by a high-fat diet
– Nan Wang & Al.
Experiment: in vivo (mus musculus – Mouse)
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This study aimed to verify whether Hericium erinaceus mushrooms could help reduce cholesterol. Researchers prepared mushroom extracts and tested them on mice with high cholesterol levels.

Results showed that Hericium erinaceus extracts effectively reduced total cholesterol, triglycerides, and LDL (“bad” cholesterol) while increasing HDL (“good” cholesterol). The researchers suggest that these mushrooms may activate enzymes that break down cholesterol.

While promising, this study was conducted on mice. Further human trials are needed to confirm these findings.

Hypolipidaemic Effect of Hericium erinaceum Grown in Artemisia capillaris on Obese Rats – Won-Sik Choi & Al.
Experiment: in vivo (ratus norvegicus – rat)
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This study evaluated the hypolipidemic effects of ethanol extracts from Hericium erinaceum cultivated with Artemisia capillaris (HEAC) in obese rats fed a high-fat diet. Rats were divided into seven groups and fed a high-fat diet for 4 weeks, followed by daily HEAC supplementation for 2 weeks.

HEAC treatment significantly reduced total cholesterol, LDL-c, and triglyceride levels while increasing HDL-c in hyperlipidemic rats. These results indicate that HEAC may effectively treat hyperlipidemia in rats and could be considered a functional food for managing hyperlipidemia in humans.