Fortifying a meal with oyster mushroom powder beneficially affects postprandial glucagon-like peptide-1, non-esterified free fatty acids and hunger sensation in adults with impaired glucose tolerance: a double-blind randomized controlled crossover trial – Lisa Dicks & Al.
Experiment: clinical study
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This study tested the effects of oyster mushroom consumption on individuals with blood sugar issues. Participants received either a meal fortified with oyster mushroom powder or a control meal. Results showed that those who consumed the mushroom-enriched meal experienced reduced hunger and more stable post-meal blood sugar levels compared to the control group.

The gray oyster mushroom, rich in beta-glucans (a type of fiber), may help reduce hunger and stabilize blood sugar in adults with glucose intolerance, suggesting its potential as a dietary supplement for blood sugar management.

Blood glucose lowering and effect of oyster (Pleurotus ostreatus)- and shiitake (Lentinus subnudus)-supplemented diet on key enzymes linked diabetes and hypertension in streptozotocin-induced diabetic in rats – Odunayo Michael Agunloye & Al.
Experiment: in vivo (Ratus norvegiscus – rat)
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Diabetic rats fed oyster or shiitake mushrooms for 14 days showed lower blood glucose, reduced activity of carbohydrate-digesting enzymes (α-amylase, α-glucosidase), higher antioxidant enzyme activity, and lower blood pressure compared to controls.
Gray oyster mushrooms and shiitake may naturally combat diabetes and hypertension.

Evaluation of antidiabetic potential of oyster mushroom (Pleurotus ostreatus) in alloxan-induced diabetic mice – Bindhu Ravi & Al.
Experiment: in vivo (Mus musculus – mouse)
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This study was conducted in diabetic mice to test the effects of feeding these mushrooms. Mice that received mushrooms had lower blood sugar, lower cholesterol, and improved kidney function compared to mice that did not receive mushrooms. Oyster mushrooms contain bioactive compounds that may help reduce blood sugar, inhibit glucose absorption, and improve kidney function.

Here is a more detailed summary of the study:

• Mice were divided into four groups: a normal control group, a diabetic control group, a group of diabetic mice treated with the standard drug glibenclamide, and a group of diabetic mice treated with oyster mushroom extract.

• After 15 days of treatment, mice in the group treated with oyster mushroom extract had significantly lower blood sugar than mice in the other groups.

• Mice in the oyster mushroom group also had lower total cholesterol, triglycerides, and LDL cholesterol than mice in the other groups.

• HDL cholesterol (the “good” cholesterol) was significantly higher in the oyster mushroom group.

• Mice in the oyster mushroom group had significantly lower creatinine and urea levels (indicators of kidney function) than mice in the other groups.

The results of this study suggest that oyster mushroom extract could be a useful natural treatment for diabetes. However, further studies are needed to confirm these results.