Hericium erinaceus proves to be a metabolic regulator of great precision, acting far beyond its traditional neurological functions. This page presents research highlighting its ability to modulate blood sugar through the inhibition of alpha-glucosidase, thereby slowing carbohydrate absorption while improving insulin sensitivity. Beyond simple sugar control, Hericium acts as a systemic protector: it preserves target organs (liver, kidneys) and supports the survival of pancreatic beta cells through its stimulating action on NGF (Nerve Growth Factor). As a comprehensive natural support, it offers an innovative approach to stabilizing metabolism and preventing nerve complications (neuropathies) and organic damage related to glycemic imbalances.

Characterization of α-glucosidase inhibitory constituents of the fruiting body of lion’s mane mushroom (Hericium erinaceus) – Seul Ki Lee & Al.
Experiment: in vitro (cell cultures)
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Summary: This in vitro study explored the antidiabetic potential of Hericium erinaceus by isolating several bioactive compounds from the fruiting body. Researchers identified ten molecules, including erinacenol D and hericenone D, capable of inhibiting α-glucosidase, a key enzyme responsible for breaking down carbohydrates into glucose. By slowing the activity of this enzyme, these compounds limit the rapid absorption of sugars, suggesting valuable support for blood glucose management. This discovery positions Hericium as a strategic natural partner for managing metabolic disorders and preventing post-prandial glycemic spikes.

Antihyperglycaemic and organic protective effects on pancreas, liver and kidney by polysaccharides from Hericium erinaceus SG-02 in streptozotocin-induced diabetic mice – Chen Zhang & Al.
Experiment: in vivo (mus musculus – mouse)
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Summary: This in vivo study evaluated the impact of Hericium erinaceus polysaccharides (HEPS) on diabetes models. Researchers observed a significant reduction in blood glucose levels, but more importantly, a marked protective effect on the pancreas, liver, and kidneys. HEPS work by limiting tissue damage associated with chronic hyperglycemia and boosting the activity of endogenous antioxidant enzymes. The findings suggest that Hericium does not merely regulate sugar but actively helps prevent major organic complications associated with diabetes by protecting cells against oxidative stress.

Erinacerins C-L, isoindolin-1-ones with α-glucosidase inhibitory activity from cultures of the medicinal mushroom Hericium erinaceus – Kai Wang & Al.
Experiment: in vitro (Cell cultures)
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Summary: This in vitro study led to the identification and characterization of ten novel bioactive compounds, named erinacerins (C to L), isolated from Hericium erinaceus cultures. Researchers demonstrated that these molecules possess significant inhibitory activity against alpha-glucosidase, the enzyme responsible for converting complex carbohydrates into simple glucose. These findings strengthen the understanding of the molecular mechanisms through which Hericium modulates blood sugar levels. As a natural enzyme inhibitor, this mushroom offers promising therapeutic perspectives for managing type 2 diabetes and metabolic control.

Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats – Bin Liang & Al.
Experiment: in vivo (ratus norvegicus – rat)
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Summary: This in vivo study explored the effects of an aqueous extract of Hericium erinaceus (AEHE) on diabetes models. The results demonstrate that prolonged administration not only promotes a significant decrease in blood glucose levels but also stimulates an increase in insulin levels. Simultaneously, the extract showed an ability to correct lipid disorders (cholesterol/triglycerides) and strengthen hepatic antioxidant defenses. By acting simultaneously on glycemic and lipid parameters, Hericium stands out as a comprehensive metabolic regulator, ideal for managing complex metabolic syndromes.

Protective Effect of Ethanol Extracts of Hericium erinaceus on Alloxan-Induced Diabetic Neuropathic Pain in Rat – Zhang Yi & Al.
Experiment: in vivo (ratus norvegicus – rat)
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Summary: This in vivo study explored the therapeutic potential of Hericium erinaceus extract (HEE) on diabetic-induced neuropathic pain. Researchers observed that prolonged oral administration not only leads to a significant reduction in blood glucose levels but, more importantly, a notable increase in pain tolerance threshold (analgesic effect on nerves). The findings suggest that Hericium acts through a dual pathway: metabolic regulation and protective antioxidant activity of nerve fibers. As both a neurological and metabolic support, Hericium emerges as a key resource for managing nerve complications related to diabetes.

NGF-withdrawal induces apoptosis in pancreatic beta cells in vitro – D. Pierucci & Al.
Experiment: in vitro (cell cultures)
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Summary: This in vitro study demonstrates that Nerve Growth Factor (NGF) is essential for the survival of pancreatic beta cells (insulin producers). Researchers observed that the withdrawal of NGF triggers apoptosis (cell death) in these cells by deactivating survival pathways (PI3K/AKT) and activating self-destruction processes. Since Hericium erinaceus is scientifically recognized for stimulating endogenous NGF synthesis, these findings suggest a potential indirect but powerful protective effect of the mushroom on pancreatic function. Hericium could thus play a key role in preserving insulin-producing cells and preventing pancreatic decline.